Exclusion of women from COVID-19 studies harms women’s health and slows our response to pandemicsCOVID-19 연구에서 여성 제외Review Published on 2022-06-082022-09-11 Journal: Biology of Sex Differences [Category] 변종, [키워드] approach clinical trial clinical trials consequence COVID-19 COVID-19 research exaggerate Gender Gender differences General health Health human population IMPROVE include Inclusion neglect pandemic Pandemics Public public health Research Sex difference sexual dimorphism Sexual dimorphism. Vaccine variant women [DOI] 10.1186/s13293-022-00435-1 PMC 바로가기 [Article Type] Review
Sex differences in global metabolomic profiles of COVID-19 patientsCOVID-19 환자의 글로벌 대사 프로필의 성별 차이Article Published on 2022-05-142022-09-11 Journal: Cell Death & Disease [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료제, [키워드] amino acids analysis aromatic amino acids Asymptomatic disease bile acid Biomarker caused change changes in clinical parameter controls coronavirus coronavirus disease correlation correlations COVID-19 COVID-19 patient COVID-19 patients death demonstrated disease examined female patient groups identification involved knowledge leads lipid metabolism male metabolic pathway metabolic pathways metabolism metabolomic Mortality pathway Patient pentose performed profile profiles researcher robust SARS-CoV-2 serum samples severe COVID-19 severe COVID-19 patient severe COVID-19 patients severe symptom severe symptoms Sex Sex difference sexual dimorphism statistical analysis susceptible Symptom target therapeutic target therapeutic targets treat Tryptophan tyrosine uninfected [DOI] 10.1038/s41419-022-04861-2 PMC 바로가기 [Article Type] Article
Sexual dimorphism in COVID-19: potential clinical and public health implicationsCOVID-19의 성 이형성: 잠재적인 임상 및 공중 보건 영향Review Published on 2022-03-012022-09-12 Journal: The lancet. Diabetes & endocrinology [Category] Fulltext, MERS, 임상, 진단, [키워드] Acute stress binding chromosome Comorbidities complement COVID COVID-19 current difference disease Endocrine Evidence explain expression pattern Follow-up help immune implication increased risk Infectious disease mechanism men Mortality outcomes pandemic Patient patients with COVID-19 progression Protein public health public health measures reaction Reinfection SARS-CoV-2 infections severity severity of COVID-19 Sex Sex difference Sex hormones sexual dimorphism Stratification Surveillance Treatment Vaccines View virus women [DOI] 10.1016/S2213-8587(21)00346-6 PMC 바로가기 [Article Type] Review
Pathogenic Infections during Pregnancy and the Consequences for Fetal Brain DevelopmentReview Published on 2022-01-312022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] ASD Autism Spectrum Disorder Bacteria Bacterial Bacterial infection brain development childhood Cognitive function cognitive impairments complications consequence Control COVID-19 pandemic Critical Cytokine storm development diagnose disease Diseases disorder disorders Effect effective fetal fetal brain development Gut Health HIV Host Human humans immune Immunity Immunocompromised Infection Inflammatory inflammatory immune response influence interleukin 17 mental health mice Microbiome Neonatal offer outcome parasite pathogen Pregnancy Prevent programming raise recent regulatory T cells resulting SARS-CoV-2 sexual dimorphism Support Symptoms T helper 17 cells thought Topic trajectory treat uterine uterine immune activation viral infections viruses [DOI] 10.3390/pathogens11020193 PMC 바로가기 [Article Type] Review
Paternally expressed gene 3 ( Pw1/Peg3 ) promotes sexual dimorphism in metabolism and behavior친밀하게 발현 된 유전자 3 (PW1/PEG3)은 신진 대사와 행동에서 성 이형성을 촉진합니다Research Article Published on 2022-01-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accelerated Adiposity adulthood age allele alteration Behavior Brain Cell cells Characteristics consequence contribute develop Diabetic Endocrine Epigenetic examined expressed expressing fat accumulation Fatty liver female genomic genomic imprinting gonadal growth hormone insulin insulin resistance life loss of function male mammal mammals manifested masculinization metabolism mice mutant observation parental pathway Peg3 phenotypic postnatal development proliferative promote provide puberty question reduced Regulation selective Sex sex steroid sexual dimorphism Signaling steroid Support tissues weaning [DOI] 10.1371/journal.pgen.1010003 PMC 바로가기 [Article Type] Research Article
Sex, immunity, and cancerReview article Published on 2022-01-012022-10-05 Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer [Category] 비임상, [키워드] Autoimmune disease Biomarker Biomarkers Cancer Cancer therapy Clinical outcome complex conditions Factors Genomics Host immune system Immunity Immunotherapy incidence infectious agent Interaction men men and women Mutation oncology Patient Prognostic value Regulation reported Sex hormones sexual dimorphism susceptibility Treatment Tumor tumor microenvironment Tumor mutational burden women [DOI] 10.1016/j.bbcan.2021.188647 [Article Type] Review article
Sex differences in the lung ACE/ACE2 balance in hypertensive ratsCardiovascular System & Vascular Biology Published on 2021-12-222022-10-28 Journal: Bioscience Reports [Category] COVID-19, [키워드] accelerate ACE ACE2 ACE2 gene ACE2 mRNA ACE2 protein Ang II Angiotensin II Angiotensin-(1-7) Angiotensin-converting enzyme angiotensin-converting enzyme 2 blood pressure coexpressed Concentration conducted coronavirus disease COVID-19 down-regulation evaluated expression female four group Genotype-Tissue Expression project Human hypertension hypertensive hypertensive patient Hypothesis lung Lung injury Lungs male Male sex mRNA level normotensive occur pathway promote Protein reduced respiratory infections sexual dimorphism significantly higher subjects tested tissue damage tissues [DOI] 10.1042/BSR20211201 PMC 바로가기 [Article Type] Cardiovascular System & Vascular Biology
Angiotensin‐Converting Enzyme 2 (SARS‐CoV‐2 receptor) expression in human skeletal muscle인간 골격근에서의 안지오텐신 분비 효소 2 (SARS -COV -2 수용체) 발현Original Article Published on 2021-10-042022-09-01 Journal: Scandinavian Journal of Medicine & Science in Spor [Category] MERS, SARS, 진단, [키워드] ACE2 ACE2 expression ACE2 protein Adiposity age analyzed angiotensin association biopsies biopsy body composition body fat cardiorespiratory cardiorespiratory fitness collected COVID‐19 determine determined by DXA enzyme exercise explained Express expression fat Interaction lean mass leg legs low fat men men and women Multiple Multiple regression analysis obesity positive Predictive Predictive value Previous studies previous study protein expression receptor regression analysis SARS‐CoV‐2 Sex difference sex differences sexual dimorphism Skeletal muscle slope subject Variability variance vastus lateralis vastus lateralis muscle VO2max was determined was reduced weight western blot women [DOI] 10.1111/sms.14061 PMC 바로가기 [Article Type] Original Article
Sexual Dimorphism and Gender in Infectious DiseasesReview Published on 2021-07-222023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Gender Infectious disease Personalized medicine Sex hormones sexual dimorphism [DOI] 10.3389/fimmu.2021.698121 PMC 바로가기 [Article Type] Review
Mucosal-associated invariant T cell responses differ by sex in COVID-19COVID-19에서 점막 관련 불변 T 세포 반응은 성별에 따라 다릅니다Article Published on 2021-06-112022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, 유전자 메커니즘, 임상, 진단, [키워드] aerosol Affair airway Apoptosis biosafety level BSL-2 BSL-3 carried Cell cells from male circulating construction content contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 sample COVID-19 samples COVID-19 susceptibility DARPA dataset Duke early infection female females flow cytometry gene signature healthy control Hospitalized IL-7 immune response immune responses immunologically individual Innate immunity integration level 2 management mechanism monocyte monocyte. mononuclear cell mononuclear cells outcomes Peripheral blood Peripheral blood mononuclear cells pro-apoptotic processed Protective Quality Quality assurance reduced reduction Regional Biocontainment Laboratory responsibility SARS-CoV-2 Sex sexual dimorphism sexual dimorphisms Single-cell RNA sequencing Support supported System T cell response tissue uninfected veteran Virology [DOI] 10.1016/j.medj.2021.04.008 PMC 바로가기 [Article Type] Article